METABOLITES OF 11-DEHYDROCORTICOSTERONE: PREGNANE-3(α), 20-DIOL-11-ONE
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چکیده
منابع مشابه
METABOLITES OF 1 l - DEHYDROCORTICOSTERONE : PREGNANE
A study’ which involved the administration of relatively large amounts of synthetic 11-dehydrocorticosterone (Ia) and its acetate2 (Ib) to a woman (Case 1) and to a man (Case 2) with Addison’s disease afforded an opportunity to determine what urinary products might be related to this hormone, Thus far it has not been possible to isolate from the urine, in cases of hyperfunctioning lesions of th...
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Deficiencies in the conversion between active and inactive glucocorticoids in the kidney can lead to hypertension. However, the significance of glucocorticoid metabolism in specific kidney regions in vivo is not clear, possibly in part due to the difficulty in measuring glucocorticoid levels in kidney regions in vivo. We used microdialysis techniques to sample renal interstitial fluid from cons...
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11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) catalyzes the conversion of the glucocorticoid corticosterone (cortisol in humans) to inert 11-dehydrocorticosterone (cortisone). 11 beta-HSD activity is present in the hippocampus, where it is induced by glucocorticoids and stress in vivo, prompting suggestions that the enzyme may attenuate the deleterious effects of chronic glucocorticoid exc...
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2014;113:1383–8. http://dx.doi.org/10.1007/s00436-014-3778-z 9. Mulec J, Vaupotič J, Walochnik J. Prokaryotic and eukaryotic airborne microorganisms as tracers of microclimatic changes in the underground (Postojna Cave, Slovenia). Microb Ecol. 2012;64:654–67. http://dx.doi.org/10.1007/s00248-012-0059-1 10. Tamura K, Peterson D, Stecher G, Nei M, Kumar S. MEGA5: molecular evolutionary genetics a...
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The mol-ecule of the title compound, C(17)H(10)O, is nearly planar, the largest deviation from the mean plane being 0.06 Å. The crystal structure is governed by π-π inter-actions, with centroid-centroid distances ranging from .559 to 3.730 Å.
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1948
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)52767-3